기초과학 자율운영 중점연구소

생명과학과에서 아래와 같이 세미나를 실시합니다.

많은 관심과 참여 부탁드립니다.

주관: 기초과학연구소(자율운영 중점연구소지원사업)

일시: 2024년 12월 11일 수요일 17:00

장소: 원천관 242호

연사: 신옥 교수(고려대학교 의과대학)

주제: Viral Strategies to Subvert Innate Immunity via Modulating Mitophagy

Abstract

It has been demonstrated that multiple viruses subvert cellular defense mechanisms by controlling the mitochondrial dynamics of the host. Selective elimination of damaged mitochondria, or mitophagy, can help maintain mitochondrial homeostasis. Recent studies on the role of mitophagy during viral infection improves our knowledge of the connections between mitophagy and viral pathogenesis. Our previous work have shown that several viruses both directly and indirectly modulate mitophagy and utilize various strategies to regulate the process. This gives viruses the powerful capacity to control and manipulate mitophagy to their advantage. In this talk, I will address the specific molecular mechanisms that various viruses employ to manipulate mitophagy for their life cycle and pathogenicity, as well as the important regulatory phases throughout viral infection in which mitophagy is implicated.